Pro-Arrhythmia
Assays available
Pro-Arrhythmia
- Digital cell geometry measurement – This assay measures sarcomere shortening and provides useful information about drug-induced pro-arrhythmia and inotropic effects.
- Current clamp electrophysiology – Action potential recordings provide pro-arrhythmia risk assessment.
Adult human ventricular trabeculae
- Electrophysiology / Sharp electrode action potential recordings – This assay provides the gold standard for human ex vivo pro-arrhythmia assessment.
Contractility Changes
Adult human ventricular trabeculae
- Trabeculae bath contraction assay – Measuring changes in contraction transients, it is possible to infer both inotropic as well pro-arrhythmia effects of compounds.
Hypertension / Hypotension
Adult human blood vessel rings
- Contraction / relaxation – This assay is used to assess the risk of drug-induced hypotensive and hypertensive effects.
Heart Rate Changes
Adult human sino-atrial node
- Electrophysiology sharp electrode recordings of spontaneous firing activity – By monitoring changes in firing frequency, this assay allows to assess the risk of drug-induced chronotropic effects.