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In additional, both the absolute–as well as the relative level of expression of critical ion channels–differs between adult human primary cardiomyocytes and human iPSC-derived cardiomyocytes, providing additional opportunities for divergent pharmacology between the two cell types.

Table 1 lists the important differences between stem cell-derived cardiomyocytes and adult human primary cardiomyocytes, including cell maturity, structure and ion channel expression.

TABLE 1

FIGURE 1

TABLE 2