Pain
Human DRG action potential firing (Electrophysiology – current clamp)
- Rheobase
- Drug inhibition of action potentials as a function of concentration and firing frequency
Drug selectivity (Calcium Imaging with Electrical Field Stimulation)
- Drug selectivity for specific neuronal subpopulations
- Cells expressing TTX-S vs. TTX-R
- A delta-like vs. C-like neurons
- Cold- vs. heat-sensing neurons
Drug selectivity (Calcium Imaging)
- Drug selectivity for specific neuronal subpopulations
- TRPV1
- TRPA1
- TRPM8
- ASIC/TRPV1
- P2X
- Opioid receptors
IC50 determination (Electrophysiology – voltage clamp)
- Nav (total)
- Nav 1.7
- Nav 1.8
- TRPV1
- TRPA1
- Kv
- Cav
Itch
Assays in isolated adult hDRG neurons
- Histamine
- Chloroquine
- Bam8-22