About Us
It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout.
It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout.
Featuring leading researchers advancing translational research
Featuring scientists advancing human-relevant drug research
Insights into contractility & electrophysiology
Insights into DRG function & sensory neuron excitability
Nav1.9 plays a defining role in pain perception, regulating resting membrane potential in human dorsal root ganglia (DRG) and trigeminal ganglion (TG) neurons and shaping how nociceptive signals are generated and sustained. Yet direct characterization of its biophysics in native human neurons—and its tractability as a selective analgesic target—has remained limited. In this webinar, AnaBios Senior Scientist Patrick Shi, Ph.D., presents original findings from native human TG and DRG neurons revealing meaningful biophysical differences between the two populations: TG neurons show faster Nav1.9 activation kinetics, a right-shifted inactivation curve, and a larger window current than DRG neurons, with direct implications for isoform-specific drug design. The data also show that inflammatory conditions potentiate Nav1.9 currents, offering a translational window into acute and chronic pain mechanisms. This work reflects the core strength of the AnaBios platform: access to physiologically intact human sensory neurons enabling target characterization not possible in animal models or heterologous expression systems.
In this installment of the AnaBios Translational Research Webinar Series, Dr. Bruce Bean examines the pivotal role of Nav1.8 voltage-gated sodium channels in controlling excitability in human dorsal root ganglion (DRG) neurons and their contribution to acute pain signaling.Dr. Bean shares new preclinical data on suzetrigine (Journavx), a selective Nav1.8 inhibitor, demonstrating how state- and temperature-dependent channel modulation influences neuronal firing under physiological conditions. These findings provide critical mechanistic insight into the therapeutic potential of Nav1.8 as a clinically relevant target for pain management.
Dr. Ted Price, Professor of Neuroscience at the University of Texas at Dallas, presents recent breakthroughs from his lab that advance our understanding of the molecular mechanisms driving chronic pain. He explores how chronic painful diseases fundamentally alter human dorsal root ganglion (DRG) neurons, highlighting transcriptomic and proteomic changes associated with diabetic neuropathic pain. Dr. Price also examines the first synapse of the pain pathway in the spinal dorsal horn, demonstrating how single-nucleus and spatial transcriptomics are being used to map this region and reveal new opportunities for therapeutic intervention.
In this live installment of the AnaBios Translational Research Webinar Series, Dr. David Salzman, CEO of Gatehouse Bio, presents the discovery of a novel microRNA isomiR shown to protect against fibrosis, based on analysis of more than 2,500 patient samples. Loss of this isomiR—observed in approximately 70% of pulmonary fibrosis patients—correlates with disease progression and adverse clinical outcomes. Dr. Salzman introduces GHB1589, a precision oligonucleotide therapy designed to restore isomiR expression and reverse fibrosis-associated tissue damage. He shares preclinical data from in vitro, in vivo, and ex vivo studies, and discusses the use of a companion biomarker to enable targeted patient stratification. Together, these findings position GHB1589 as a first-in-class therapeutic approach for pulmonary fibrosis.
