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AnaBios offers high-quality human tissue and cells recovered through our extensive network of hospitals and organ procurement organizations. We utilize proprietary methods, practices and streamlined logistics to maximize the preservation of physiological function. Our goal is to deliver industry-leading human tissues and cells for scientific research and drug discovery.
AnaBios creates the unprecedented opportunity for researchers to develop safer, more effective drugs while reducing time-to-market and clinical development costs. Accordingly, we have developed proprietary processes for functional ex vivo human platforms that redefine the concept of “First in Human” studies and bring true human biology to early pre-clinical discovery.
In a recent Frontiers in Pharmacology publication, scientists from the U.S. Food and Drug Administration and AnaBios collaborated to better understand how drug effects on multiple cardiac ion channels translate from nonclinical studies to clinical ECG outcomes. The findings demonstrate that experimental design and human-relevant models are critical for accurately interpreting multi-ion channel effects on cardiac electrophysiology.
Primary somatosensory neurons in the DRG play critical roles in sensing external and internal stimuli and generate sensations like pain, itch, warm, cold and touch. Most knowledge regarding DRG neurons comes from model organisms, which may have significant species differences from humans. Dr. Wenqin Luo, Associate Professor of Neuroscience at the University of Pennsylvania, discuss her research team’s work developing a new approach by isolating individual somas of human DRG neurons using laser capture microdissection and performing high-depth Smart-seq2 RNAseq.
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