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HUMAN HEART TISSUE FOR DRUG DISCOVERY

The human heart is a complex organ of distinct sub-structures, different tissue types and cellular architectures that work in a coordinated fashion to pump blood throughout the body (Figure 1). Tissue distribution, cellular composition and gene expression vary throughout the heart to match regional function. Such organ complexity is precisely why AnaBios offers a suite of anatomically distinct human tissue samples that cover the breadth of cardiac functions (Table 1). 

Figure 1. Schematic of the human heart
Table 1. AnaBios Human Cardiac Tissue Areas

Aorta

Endocardium

Aortic Valve

Epicardium

Aortic Semilunar Valve

Mitral Valve

Ascend Coronary

Papillary

Atrium Appendage

Pulmonary Semilunar Valve

Atrium Trabecula

Septum

Atrium Wall

Sinoatrial Node

Bicuspid Valve

Subclavian Artery

Brachiocephalic Artery

Tricuspid Valve

Carotid Artery

Ventricle

Circumflex Artery

Ventricular Outflow Tract

Coronary

Ventricular Purkinje

Descend Coronary

Ventricular Trabecula

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USING HUMAN CARDIAC TISSUE FOR HEART FAILURE & CARDIOTOXICITY RESEARCH

Heart failure remains a leading cause of death and cardiotoxicity is a major contributor to late-stage failures in drug development. High-quality human cardiac tissue samples provide a strong translational foundation for ensuring appropriate therapeutic target expression and localization while providing insight as to potential toxic interactions and safety concerns.

AnaBios has been enabling clinical success with high quality cardiac tissue samples precisely matched and prepared to individual program needs for over 11 years. Let us jump-start your success with both healthy and diseased human heart tissue samples.

QUALITY IS KEY: THE ANABIOS ADVANTAGE

The AnaBios Advantage minimizes ischemic/reperfusion injury to provide the highest quality tissue samples for the most accurate and translatable results. Tissue sample quality is exemplified in two primary areas. 

First is the ability of AnaBios to provide functional cardiac assays as outlined by our CardioPRIME® and other functional offerings. Second is the industry-leading RNA integrity number (RIN) scores. The AnaBios Advantage and quality systems ensure tissues samples with consistently high RIN scores across donors. Starting with high-quality data enables the highest quality results. 

HEALTHY & DISEASED HUMAN HEART TISSUE

Different Formats to Meet Drug Discovery Program Needs

AnaBios provides a variety of fixed and frozen off-the-shelf human tissue samples from our biorepository, as well as proactive custom recoveries from healthy and diseased organ donors. Table 2 below is a non-exclusive listing of tissue types and structures. 

AnaBios prepares tissue samples for downstream omics work, immunocytochemistry, in-situ hybridization and more. Contact us for additional information on donor demographics and sample types from heart failure, atrial fibrillation, hypertrophic cardiomyopathy, coronary artery disease and other heart conditions.

Table 2: Human Heart Tissue Types & Structures

HEART TISSUE TYPE

EXAMPLE SAMPLES

Ventricular (left & right chambers)

Myocardial musculature, papillary muscle, Purkinje fibers, trabeculae, ventricular outflow tracts

Atrial (left & right chambers)

Myocardial musculature, Purkinje fibers, right and left appendages, trabeculae

Pace making

Sino-atrial node

Circulatory

Artery, aorta, brachiocephalic, carotid, circumflex, subclavian vein, coronary (ascending & descending), pulmonary

Valves

Aortic, aortic semilunar, bicuspid, mitral, pulmonary semi-lunar

Miscellaneous

Septum

ACCESS OUR HEART RESEARCH WEBINARS

Dr. Najah Abi-Gerges, Vice President of Research & Development at AnaBios, demonstrates how human primary cardiomyocytes can be used to predict inotropes. This novel platform can be used to enhance drug discovery programs and better guide decision-making.  

Get access to more cardiac research webinars, as well as poster, publications and brochures, in our library. Click on the button to the right to access it.

MORE CARDIAC RESEARCH WEBINARS

  1. Luo et al. (2021) Nature Scientific Reports  Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction   https://www.nature.com/articles/s41598-021-91214-2
  2. Okada et al (2022) Biomolecules Comparative Study of Transcriptome in the Hearts Isolated from Mice, Rats, and Humans   https://www.mdpi.com/2218-273X/12/6/859
  1. Kifoil et al. (2021) European Journal of Pharmacology  Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters https://www.sciencedirect.com/science/article/pii/S0014299921007408

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