Human brain tissue samples from various regionsLearn More
Foundational Data for Successful Clinical Translational
AnaBios is one of the only CROs in the U.S. with access to a vast network of hospitals with human tissue & organs from consented donors. We provide the highest-quality human tissue samples and cells for biological research.
CLINICAL SUCCESS STARTS AT THE BEGINNING
Successful drug discovery depends on a relevant and robust foundation that can drive effective clinical translation. AnaBios lays this groundwork in the form of high-quality, primary human tissue samples and cells. AnaBios leverages a nationwide network of hospitals and organ procurement organizations and uses proprietary solutions, practices and streamlined logistics that minimize ischemic and reperfusion injury to deliver industry-leading human tissues and cells for scientific research.
QUALITY IS KEY
The high quality of our human tissue is demonstrated by their industry-leading RNA Integrity Number (RIN) scores. Higher RIN scores are a measure of tissue quality, confirm a closer identity to the native state, and deliver a stronger resource for translational target identification, omics-based analyses, and more. Figure 1 illustrates how the AnaBios processes result in higher RIN scores as compared with other commercial sources.
HUMAN TISSUE RIN SCORES
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RNA INTEGRITY NUMBERS (RIN)
The high quality of AnaBios procured tissue is verified through the RNA Integrity Number (RIN) score. Higher RIN scores equate to higher quality tissue with less RNA degradation (Schroeder et al., 2006) and preservation of critical activity-dependent genes that more susceptible to postmortem RNA degradation (Dachet et al., 2021).
Our RIN scores are determined via the Agilent BioAnalyzer 2100 and Expert Analysis Software and mean values from healthy tissue (above) show 25% to 40% higher than those from other suppliers (in-house data compared to that of the GTEx Consortium). The Industry-leading RIN scores from AnaBios healthy and diseased tissue ensures the highest quality human tissue for discovery programs.
FORMATTED TO DRIVE ACTIONABLE RESULTS
AnaBios has an existing and growing biobank of human tissue samples and cells that enable down-stream investigations.
- From milligrams to grams AnaBios tissue samples provide enough material for a variety of ‘omics and immunocytochemical analyses.
- Prospective collections can be customized for anatomical location and sample size that precisely meet your needs.
- Samples are flash-frozen, fixed with or without additional agents, or can be prepared with custom instructions for your needs.
ETHICALLY-SOURCED HUMAN TISSUE FOR SCIENTIFIC RESEARCH
AnaBios recognizes the stewardship that comes with human tissue samples. As such, all tissue samples are recovered and processed with proprietary methods that maximize tissue integrity and physiological function (where appropriate). Our tissue quality control, based on RIN scores and measurements of physiological function, provides a unique guarantee of exceptional quality and the highest grade for supporting scientific research and drug discovery.
Our human tissue samples and cells are recovered only within the United States. All recoveries follow informed consent procedures that meet or exceed standard guidelines concerning consent for human organ donation for research in a “for profit” environment as established by industry practice and governed by the Uniform Anatomical Gift Act (UAGA). Only anonymized and/or de-identified patient information is provided by AnaBios, as defined in the Health Insurance Portability and Accountability Act (HIPAA).