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It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout.
This study shows that subsets of colon-innervating sensory neurons in mice express, either individually or in combination, the pruritogenic receptors Tgr5 and the Mas-gene-related GPCRs Mrgpra3 and Mrgprc11. The in vivo intracolonic administration of these individual agonists induced pronounced visceral hypersensitivity to colorectal distention with coadministration augmenting hypersensitivity to colorectal distension and mouse behavior. The data supports the existence of an irritant-sensing system in the colon that is a visceral representation of the itch pathways found in skin.
PUBLICATION: JCI Insight (2019)
AUTHORS: Joel Castro, Andrea M. Harrington, TinaMarie Lieu, Sonia Garcia-Caraballo, Jessica Maddern, Gudrun Schober, Tracey O’Donnell, Luke Grundy, Amanda L. Lumsden, Paul Miller, Andre Ghetti, Martin S. Steinhoff, Daniel P. Poole, Xinzhong Dong, Lin Chang, Nigel W. Bunnett and Stuart M. Brierley