Drug development and toxicology studies rely heavily on animal models which often inaccurately predict the true response for human exposure leading to unanticipated adverse effects. This paper outlines the use of our multi-electrode array (MEA) platform for long-term noninvasive assessment of human dorsal root ganglia (hDRG) cell health and function. This first report on long-term measurement for hDRG on a MEA platform marks the way for customized arrangements as well as integration with different tissue types on a single device in the future.

PUBLICATION: Gut (2017)

AUTHORS: H. A. Enright, S. H. Felix, N. O. Fischer, E. V. Mukerjee, D. Soscia, M. Mcnerney, K. Kulp, J. Zhang, G. Page, P. Miller, A. Ghetti, E. K. Wheeler and S. Pannu