Gadolinium based contrast agents are widely used in MRIs and are all based on chelated Gd3+. This study attempts to elucidate the detailed mechanism of Gd3+-induced pathology by investigating the effects of Gd3+ in cultured hDRG neurons. The study found that Gadolinium can directly activate a large population of human nociceptive DRG neurons.

AUTHORS: Jingming Zhang, Guy Page, Heather Enright, Windy Mcnerney, Erik Mukerjee, Elizabeth Wheeler, Satinderpall Pannu, Kris Kulp, Fang Qian, Paul Miller, Ada Silos‐Santiago and Andre Ghetti