The Nav1.8 TTX resistant (TTX-r) voltage-gated sodium channel was characterized from human DRG and pharmacologically proven using a selective blocker. Under the small dataset and recording conditions it was shown both biophysically and pharmacologically that Nav1.8 is present and functional in human DRG and that the properties of recombinant hNav1.8 channels expressed in a variety of neuronal and non-neuronal backgrounds closely resemble those of the native channel.
AUTHORS: Liz Payne, Victor A. Panchenko, Andrea Ghetti, Ari Alexandrou, Paul E. Miller, Edward Stevens