By adding proinflammatory or neuropathogenic agents to DRG culture conditions, this study investigated how the physiological properties of cells are altered in our pain models. The successful establishment of our human ex vivo models for inflammation and chemotherapy-induced neuropathy are powerful tools to predict the therapeutic efficacy of lead compounds under specific pain conditions.

AUTHORS: Andre Ghetti, Yannick Miron, Anh-Tuan Ton, Tim lndersmitten, Nathalie Nguyen, Phachareeya Ratchada, Ashley Alamillo, Katrina Sweat, Ismael Tapia, Guy Page and Paul Miller