Single-cell patch-clamp reverse transcriptase-quantitative polymerase chain reactions were used to clarify the composition of the iCell cardiomyocyte population to compare with atrial and ventricular cardiomyocytes. This comparison provided evidence that may hamper the interpretation of drug effects parameters depending on a combination of ionic currents, such as beat rate, and supports the evaluation of drug effects in a more realistic cardiomyocyte environment. 

PUBLICATION: Cells (2021)

AUTHORS: Christina Schmid, Najah Abi-Gerges, Michael Georg Leitner, Dietmar Zellner and Georg Rast