The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. This paper aimed to discover more potent and selective drug like NCX 1.1 inhibitor. ORM-11372 was found to be a positive inotropic compound and potent inhibitor of human and rat NCX 1.1.
PUBLICATION: British Journal of Pharmacology (2020)
AUTHORS: Leena Otsomaa, Jouko Levijoki, Gerd Wohlfahrt, Hugh Chapman, Ari-Pekka Koivisto, Kaisa Syrjänen, Tuula Koskelainen, Saara-Elisa Peltokorpi, Piet Finckenberg, Aira Heikkilä, Najah AbiGerges, Andre Ghetti, Paul E. Miller, Guy Page, Eero Mervaala, Norbert Nagy, Zsófia Kohajda, Norbert Jost, László Virág, András Varró and Julius Gy. Papp