banner
A Human Cardiomyocyte-Based Platform for the Profiling of Drug-Induced Effects on Cardiac Contractility: Predicting Inotropic Mechanisms of Action

Drug-induced effects on cardiac contractility can lead to serious adverse events including heart failure and limit the utility of innovative treatments. AnaBios sought to develop a human cardiomyocyte contractility assay that has the potential to simultaneously predict drug-induced inotropic risk and generate multi-parameter data to profile different inotropic mechanisms of action. The created adult human primary cardiomyocyte-based platform is scalable, efficient, and predictive for preclinical risk management.

AUTHORS: Najah Abi-Gerges, Tim Indersmitten, Ky Truong, William Nguyen, Nathalie Nguyen, Guy Page, Paul E Miller and Andre Ghetti