AnaBios News


NIH/NCATS Awards SBIR Grant to AnaBios for Developing Novel Pain Therapeutics

SAN DIEGO, CA – December 15, 2020 – The National Institute of Health (NIH) and its subdivision, the National Center for Advancing Translational Sciences (NCATS), has awarded AnaBios a Phase I Small Business Innovation Research (SBIR) grant to further advance its unique human dorsal root ganglia (DRG) platform for pre-clinical drug discovery. In this NIH/NCATS-sponsored program, AnaBios will develop a battery of assays for a translational drug screening platform that will generate human-relevant data to assess the potential of a drug candidate’s activity in specific pain states. “AnaBios appreciates the NIH’s continued support of our efforts to develop tools [...]

December 15th, 2020|

AnaBios and Orion Publish Scientific Article Describing Novel Cardiac Compound

SAN DIEGO, October 29, 2020 ( - Today, AnaBios Corporation announced the publication of a peer-reviewed article which provides the latest example of its innovative human drug development paradigm. The work, conducted in collaboration with Orion Corporation and researchers at the Faculty of Medicine in Helsinki, Finland, and at the Faculty of Medicine, University of Szeged, Hungary, focused on a new compound targeted against a cardiac protein implicated in heart failure, ischemia and arrhythmia. The paper, entitled “Discovery and characterization of ORM-11372, a unique and positively inotropic sodium-calcium exchanger/inhibitor,” was published in the British Journal of Pharmacology. AnaBios conducts physiology experiments with [...]

October 29th, 2020|

CCO Dr. Chris Mathes Interviewed by Ion Channel Library

AnaBios Chief Commercial Officer Dr. Chris Mathes was recently interviewed by Ion Channel Library about his career in the biotech industry, the automated patch clamp sector and AnaBios' human tissue platform. Click here to read the full interview.

October 1st, 2020|

Legal Drugs Podcast Interviews AnaBios’ Chris Mathes

Legal Drugs Podcast Host Angela Stoyanovich recently interviewed AnaBios Chief Commercial Officer Dr. Chris Mathes about the company's new pain research project with Eli Lilly to develop a human spinal cord preclinical assay that measures electrophysiological properties. Watch the full interview below.

August 4th, 2020|

NIH/NCATS Awards $1.1M SBIR Grant to AnaBios to Develop Preclinical Research Technology Utilizing Adult Human Primary Cardiomyocytes

SAN DIEGO, CA – March 31, 2020 – The National Institute of Health (NIH) and its subdivision,  the  National Center for Advancing Translational Sciences (NCATS), recently awarded AnaBios a 12-month Small Business Innovation Research (SBIR) grant in the amount of $1,132,289 to develop a novel technology to measure physiological parameters in adult human primary cardiomyocytes. The new technology will allow AnaBios to evaluate thousands of compounds per year in support of medicinal chemistry efforts and preclinical cardiac risk assessment in a truly translational assay. Identifying the cardiotoxicity risk of a drug in advance of clinical studies remains a major challenge [...]

March 31st, 2020|

Human Tissue-Based Drug Discovery and the Ability to Fight the Coronavirus Pandemic

The Emergency The unfolding crisis created by the coronavirus pandemic is triggering extraordinary efforts by the scientific community to generate new antiviral medications. There are two principal strategies for antiviral drug development: (1) repurpose existing drugs (or combinations thereof) or (2) develop a new antiviral medication. While both strategies are being fast-tracked at each stage of the drug discovery process, a successful response to this emergency will require BOTH an accelerated timeline AND accurate, reliable data to ensure new drugs are safe and effective. The Challenge The traditional paradigm for assessing a new drug’s potential safety and efficacy utilizes animal [...]

March 26th, 2020|

CEO Message: Critical Research Needed to Fight the Coronavirus Pandemic

These challenging times call for united social and corporate responsibilities, as well as meaningful actions, that can help mitigate and, ultimately, overcome the coronavirus global pandemic. As an innovative biotechnology company, AnaBios is focused on how drugs work in humans to treat and prevent diseases. The first critical step in tackling a disease is to understand how it develops in humans. For Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which causes COVID-19, the scientific insight is rapidly advancing as a result of significant effort by clinicians and scientists across the globe. Nonetheless, there remains a tremendous level of uncertainty about the [...]

March 23rd, 2020|

AnaBios to Develop Drug Screening Assays Based on Human Spinal Cord Tissue

SAN DIEGO, CA – March 10, 2020 – Today, AnaBios announced a collaboration with Eli Lilly and Company (Lilly) to develop proprietary electrophysiology assays for preclinical drug discovery research. The collaboration will leverage AnaBios’ expertise in the recovery and interrogation of human cell and tissue samples. The project will focus on ethically-consented samples of human spinal cord and provide an unprecedented preclinical paradigm for studying how new drug candidates can modulate the transmission of sensory and motor information between the brain and peripheral tissues. “AnaBios is excited to work with Lilly to develop these new human central nervous system [...]

March 10th, 2020|

FDA Inks Research Collaboration Agreement with AnaBios Focused on Human Primary Cardiomyocytes

SAN DIEGO, CA – March 10, 2020 – Today, AnaBios announced a Research Collaboration Agreement (RCA) with the U.S. Food and Drug Administration (FDA) to study adult human primary cardiomyocytes as a reference for cellular properties and drug-induced effects on cardiac function. Under the RCA, the FDA Center for Drug Evaluation and Research (CDER) and AnaBios will evaluate functional human primary cardiomyocytes as standards for reference of gene expression, localization of functional proteins and sensitivity of their functional properties to inotropic drugs, i.e. those that affect the strength of cardiomyocyte contractility. “AnaBios is pleased to collaborate with the FDA at [...]

March 9th, 2020|

AnaBios CEO Interviewed by Legal Drugs Podcast

AnaBios CEO Dr. Andre Ghetti was recently interviewed by Angela Stoyanovitch, host of the Legal Drugs Podcast. They discussed the challenges of overcoming animal model data. Dr. Ghetti discusses case studies that demonstrate the need for relevant, predictive data at the preclinical drug discovery stage to better guide decision-making processes. He also discusses the challenges AnaBios has overcome, as well as future challenges Listen to the full podcast here.

January 7th, 2020|

FDA Awards AnaBios Contract to Obtain Critical Translational Data from Ex Vivo Human Cardiac Platform

SAN DIEGO, CA – November 5, 2019 – The U.S. Food and Drug Administration (FDA) has awarded AnaBios an exclusive Indefinite Delivery Indefinite Quantity (IDIQ) contract to employ adult human primary tissues and cardiomyocytes from organ donors to assess drug safety related to cardiac function. “AnaBios is very honored to receive this contract from the FDA for this important project related to the cardiac safety assessment of drugs,” said Dr. Paul E. Miller, co-founder and Chief Corporate Development Officer of AnaBios. “For over a decade, AnaBios has worked diligently to develop a translational ex-vivo human heart platform. We anticipate [...]

November 4th, 2019|

AnaBios Wins NCATS ASPIRE Award to Further Develop Preclinical Pain Assays Using Human Sensory Neurons

SAN DIEGO, CA – September 25, 2019 – The National Center for Advancing Translational Sciences (NCATS) awarded AnaBios the ASPIRE Design Challenge award in the category entitled, “Biological Assays for Translational Innovation in Pain, Opioid Use Disorder and Overdose.” Funds from the award will be used to study ex vivo human models of pain for translational drug discovery. “AnaBios is honored to receive this recognition from NCATS for providing important innovations in preclinical pain research,” said Dr. Andre Ghetti, Chief Executive Officer of AnaBios. “We appreciate the recognition from the Helping to End Addiction Long-term (HEAL) Initiative and are [...]

September 25th, 2019|
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