To assess drug-induced pro-arrhythmic risk, new models such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs) have been proposed. The findings indicated that SC-CMs exhibited immature phenotype and had the propensity to generate false positives in predicting Torsades de Pointe (TdP) risk. Human ventricular trabeculae (hVT) were used to evaluate drugs to expand the knowledge base. The hVT AP-based model combined with the integrated analysis of pro-arrhythmic score was found to have a greater predictive performance when compared to human SC-CM models.

PUBLICATION: Frontiers in Physiology (2018)

AUTHORS: Yusheng Qu, Guy Page, Najah Abi-Gerges, Paul E. Miller, Andre Ghetti and Hugo M. Vargas