Publications and Resources

Publications and Resources 2018-10-04T13:00:53+00:00

Learn how AnaBios’ proprietary human-based technology has helped top pharma and biotech firms improve the safety and efficacy of their novel compounds throughout the drug discovery process.

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Effect of Ozanimod (RPC1063) on Action Potential Parameters in Adult Human Purkinje Fibres. N. Abi-Gerges, P. Miller, A. Ghetti, F. Scott, K. Meadows, B. Clemons, P. Frohna, G. Page and G. Opiteck.

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Adult Human Primary Cardiomyocyte Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-Arrhythmia Risk. N. Nguyen, W. Nguyen, B. Nguyenton, P. Ratchada, K. Truong, G. Page, P. Miller, A. Ghetti and N. Abi-Gerges.

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Action Potential Recording and Pro-Arrhythmia Risk Analysis in Human Ventricular Trabeculae. Y. Qu, G. Page.

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Carbamazepine and CNV 1427400 Exhibit Similar Pharmacology in Recombinant Systems, Rat and Human Native DRGs. S. N. Tate, F. Rugiero, D. Derjean, V.A. Panchenko, D. Owen, A. Ghetti, K. Bannister, M. Thakur, A.H. Dickenson, P. Miller et al)

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Extracellular Cyclic GMP (cGMP), the Downstream Mediator Released In Response to Linaclotide-Induced Activation of Guanylate Cyclase-C (GC-C), Reduces Excitability of Murine and Human Dorsal Root Ganglion Neurons. J. Castro, G. Rychkov, A. Ghetti, A. Harrington, C. Kurtz et al.

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Phenotypic Profiling of Human Dorsal Root Ganglion Neurons. J. Zhang, Y. Miron, G. Page, B. Copits, S. Davidson, P. Miller, R. Gereau, A. Ghetti.

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High-Content Functional Imaging Reveals Differential Effects of Inflammation on Two Distinct Populations of Human Nociceptive Neurons. Y. Miron, J. Zhang, G. Page, C. Ghetti, B. Copits, S. Davidson, R. Gereau, P. Miller, A. Ghetti.

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Direct Activation Induced by Gadolinium in Cultured Human DRG Neurons. J. Zhang, G. Page, H. Enright, W. Mcnerney, E. Mukerjee, E. Wheeler, A. Ghetti, et al.

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TRPM8-Mediated Response to Cold in Human DRG Neurons and Modulation by the Chemotherapy Agent Oxaliplatin. A. Ghetti, J. Zhang, Y. Miron, J. Stretton, K. Morrison, et al.

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Biophysical and Pharmacological Characterisation of Native Human Nav1.8 Channels from Isolated Dorsal Root Ganglia (DRG). L. Payne, V. Panchenko, A. Ghetti, A. Alexandrou, P. Miller, E. Stevens, et al.

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Sensory Neuron Hyperexcitability Is Prevented by Group 2 Metabotropic Glutamate Receptors in Mouse and Human. S. Davidson, J. Golden, G. Page, J. Zhang, A. Ghetti and R. Gereau.

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Human Sensory Neurons: Excitability, Sensitization and Multiple Potassium Channel Conductances. S. Davidson, B. Copits, J. Zhang, G. Page, A. Ghetti and R. Gereau.

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Tailoring Chronic Pain Treatments for the Elderly: Are We Prepared for the Challenge? S. Americ, J. Laird, A. Chappell, J. Kennedy.

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A Human Ex-Vivo Contractility-Based Assay for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-Arrhythmia Risk.
 N. Abi-Gerges, A. Alamillo, P. Ratchada, G. Page, Y. Miron, N. Nguyen, P. Miller and A. Ghetti.

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Computational Cardiology and Risk Stratification for Sudden Cardiac Death: One of the Great Challenges for Cardiology in the 21st Century. A. Hill, M. Perry, N. Abi-Gerges, J. Couderc, B. Fermini, J. Hancox, B. Knollmann, G. Mirams, J. Skinner, W. Zareba and J. Vandenberg. 2016

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Human-Based Approaches to Pharmacology and Cardiology: An Interdisciplinary and Intersectional Workshop. B. Rodriguez, A. Carusi, N. Abi-Gerges, A. Ghetti, et al. 2016

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Adult Human Primary Cardiomyocytes: An Integrative Translational Model for Preclinical Drug Testing. N. Nguyen, N. Abi-Gerges,  P. Ratchada, G. Page, Y. Miron, , P. Miller and A. Ghetti. 2016

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Human Sensory Neurons: Membrane Properties and Sensitization by Inflammatory Mediators. S. Davidson, B. Copits, J. Zhang, G. Page, A. Ghetti, R. Gereau. 2014

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Astrocytes Contribute to Gamma Oscillations and Recognition Memory. H. Lee, A. Ghetti, A. Pinto-Duarte, X. Wang, G. Dziewzapolski, F. Galimi, et al. 2014

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Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine and Verpamil Between Human Ex Vivo Trabeculae and In Silico Ventricular Models Incorporating Inter-Individual Action Potential Variability. O. Britton, N. Abi-Gerges, G. Page, A. Ghetti, P. Miller, B. Rodriguez. Published in “Frontiers in Physiology.” 2017

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Long-Term Non-Invasive Interrogation of Human Dorsal Root Ganglion Neuronal Cultures On An Integrated Microfluidic Multielectrode Array Platform. G. Page, H. Enright, S. Felix, E. Mukerjee, D. Soscia, et al. 2016

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Human Ex-Vivo Action Potential Model for Pro-Arrhythmia Risk Assessment. G. Page, P. Ratchada, Y. Miron, G. Steiner, A. Ghetti, P. Miller, J. Reynolds, N. Abi-Gerges, et al. 2016

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Adult Human Primary Cardiomyocyte-Based Platform for the Profiling of Positive Inotropes with Potential to Treat Heart Failure. N. Abi-Gerges, T. Indersmitten, K. Truong, W. Nguyen, I. Tapia, N. Nguyen, G. Page, A. Ghetti and P. Miller. 2018

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Chronic Linaclotid Treatment Reduces Colitis-Induced Neuroplasticity and Reverses Persistent Bladder Dysfunction. L. Grundy, A. Harrington, J. Castro, S. Garcia-Caraballo, A. Deiteren, J. Maddern, G. Rychkov, P. Ge, S. Peters, R. Feil, P. Miller, A. Ghetti, G. Hannig, et. al. 2018

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