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Whole cell patch-clamp electrophysiology was used to investigate the in vitro properties of Carbamazepine and CNV1427400, a novel sodium channel blocker, in human recombinant sodium channels, rat DRGs and human native DRGs from health donors. The human native and recombinant Navs, Carbamazepine and CNV1427400 show similar potency and state-dependent mechanism of block, translating into a similar frequency-dependent inhibition of action potential firing in rat and human native DRGs.
AUTHORS: S.N. Tate, F. Rugiero, D. Derjean. V.A. Panchenko, D. Owen, A. Ghetti, K. Bannister, M. Thakur, A.H. Dickenson, P. Miller, V. Morriset