This paper investigates if a human ex-vivo AP-based model could provide a more predictive approach for assessing pro-arrhythmic risk. The effects of dofetilide, dl-sotalol, quinidine, paracetamol, and verapamil on action potential (AP) duration and recognized pro-arrhythmia predictors, triangulation, and incidence of early afterdepolarizations were evaluated. The model provided an integrative translational assay assisting in shaping clinical development plans that could be used in conjunction with the new CiPA-proposed approach.

PUBLICATION: Journal of Pharmacological and Toxicological Methods (2016)

AUTHORS: Guy Page, Phachareeya Ratchada, Yannick Miron, Guido Steiner, Andre Ghetti, Paul E. Miller, Jack A. Reynolds, Ken Wang, Andrea Greiter-Wilke, Liudmila Polonchuk, Martin Traebert, Gary A. Gintant, Najah Abi-Gerges