Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac diseases, mutations, and drug action and are not entirely understood in humans. The aims of this study were to present novel human PCs electrophysiology biophysically detailed computational model, and to disentangle ionic mechanisms of human Purkinje-related electrophysiology, pacemaker activity and arrhythmogenicity. The model used unlocked further investigations into the role of cardiac Purkinje in ventricular arrhythmias through computer modelling and multiscale simulations.

PUBLICATION: Journal of Molecular and Cellular Cardiology (2020)

AUTHORS: Cristian Trovato, Elisa Passini, Norbert Nagy, Andras Varro, Najah Abi-Gerges, Stefano Severi and Blanca Rodriguez