To combat challenges in assessing drug effects on cardiac contractility, the development of an adult primary cardiomyocyte contractility model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic effect is needed. The contractility model used in this paper could accurately facilitate informed mechanistic-based decision making, risk management and discovery of molecules with the most desirable pharmacological profile for heart failure correction.

PUBLICATION: Scientific Reports (2020)

AUTHORS: Najah Abi-Gerges, Tim Indersmitten, KyTruong, William Nguyen, Phachareeya Ratchada, Nathalie Nguyen, Guy Page, Paul E. Miller & Andre Ghetti