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A lack of human-specific data and appropriate model techniques have previously prevented quantitative comparison of drug effects between in silico models and recordings from human cardiac preparations. This paper compares changes in repolarization biomarkers caused by dofetilide, dl-sotalol, quinidine, and verapamil, between in silico populations of human ventricular cell models and ex vivo human ventricular trabeculae.
PUBLICATION: Frontiers in Physiology (2017)
AUTHORS: Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller and Blanca Rodriguez