Expression of metabotropic glutamate receptor 2 (mGlu2) was studied in mouse and human DRGs. The mGlu2 activation or potentiation of endogenous activity was found to prevent and reverse indicators of pain. mGlu2 immunoreactivity is present in medium sized DRG neurons.
AUTHORS: Steve Davidson, Judith P. Golden, Guy Page, Jingming Zhang, Andrea Ghetti, and Robert W. Gereau IV