Cold allodynia is often experienced by individuals with chemotherapy-induced peripheral neuropathy (CIPN). This study monitored immunoreactivity of TRPM8, a prime candidate for the transduction of low temperature-induced pain, in human DRGs. It found that TRPM8 may significantly contribute to the reported cold allodynia.

AUTHORS: Andre Ghetti, Jingming Zhang, Yannick Miron, Jennifer Stretton, Kerrie Morrison, Paul Murdock, Keith Page and Paul E Miller