QUALITY. GUARANTEED.
AnaBios is one of the only CROs in the U.S. with access
to a vast network of hospitals with human tissue & organs
from consented donors.
DOWNLOAD OUR HUMAN TISSUE CATALOGS
| AF, CHF, CAD | Muscle, vasculature, valves, fixed cardiomyocytes, cryopreserved fibroblasts | Genomic sequencing (tissue, cells), proteomics, metabolomics, IHC |
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| Chronic inflammatory pain, neuropathy | Ganglia (Thoracic through sacral), fixed neuronal cultures | Genomic sequencing (tissue), RNAscope, proteomics, IHC |
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| Please inquire | Tissue sections | Genomic sequencing (tissue), RNAscope, proteomics, IHC |
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| Please inquire | Lung tissue, precision-cut lung slice (live) | Genomic sequencing (tissue), RNAscope, proteomics, IHC, live assays |
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| Please inquire | Small and large intestine, colon and live sections | Genomic sequencing (tissue), RNAscope, proteomics, IHC, live assays | |
| Please inquire, cirrhosis, NASH, NAFLD | Liver samples (bulk and punch), frozen hepatocytes | Genomic sequencing (tissue), RNAscope, proteomics, IHC | |
| CKD | Kidney samples (bulk and punch) | Genomic sequencing (tissue), RNAscope, proteomics, IHC | |
| Please inquire | Intact eye | — | |
| Please inquire | — | — |
RNA Integrity Numbers (RIN)
The RNA quality of human organs recovered and preserved by AnaBios was assessed using RNA integrity numbers (RIN) determined by an Agilent Bioanalyzer. Total RNA was extracted and isolated from homogenized human tissue samples that were either preserved by flash freezing in liquid nitrogen or by immersion in RNAlater. Aliquots of extracted total RNA were run on the Bioanalyzer, and the integrity of the RNA was assessed by the ratio of the peaks of 28S and 18S ribosomal RNA. Mean RIN scores per tissue type (healthy donors) are shown in the graph (error bars = standard deviation). High quality RNA that can be used for expression analysis is indicated by a RIN score greater than 7, which indicates that RNA remains intact and not degraded during tissue recovery. All RIN scores were consistently above 7 with mean scores above 9. Diseased tissue samples have similar high quality.
Physiologically Functional Tissue for Drug Discovery
AnaBios use human tissue samples from consented organ donors to measure drug activity employing physiologically relevant endpoints. Laboratory equipment developed at AnaBios for electrical field stimulation (EFS) provides an efficient and sensitive methodology for investigating the modulation of different subtypes of voltage-gated channels in human cells in culture.
FREQUENTLY ASKED QUESTIONS
What’s the difference between AnaBios’ human tissue and that of biobanks and tissue repositories?
AnaBios takes strict protocol measures to ensure the viability and functionality of the tissue and organs ethically-procured from donors. Our methodologies for preserving the tissue focuses on utilizing solutions that temporarily induce metabolic arrest and slow down the ischemic breakdown process. This approach halts the depletion of intracellular ATP and creates an ionic transmembrane balance compatible with the preservation of tissue integrity.
Does AnaBios offer diseased tissue for academic and biotech research?
AnaBios offers normal and diseased high-quality human tissue for both academic and pharmaceutical research, and provides demographic information, such as sex, age, race and BMI. Please contact us for more information about our diseased tissue.
Does AnaBios ship human tissue to locations outside of the United States?
Currently, AnaBios has limited capability to ship human tissue samples outside of the United States. However, we are working with shipping carriers to expand our ability to ship beyond the United States.